histone methylation

Molecular Mechanism of Plant Flowering Regulated by Histone Methylation

植物开花的组蛋白甲基化调控分子机理

SET domain proteins contain conserved SET domains , which intensively involved in histone methylation .

SET蛋白是一类包含保守的SET结构域、与组蛋白甲基化密切相关的蛋白质。

Some scholars have found a high proportion of histone methylation in prostate cancer patients .

有学者发现前列腺癌患者中组蛋白甲基化的比例很高。

The Relationship of DNA Methylation and Histone Methylation

DNA甲基化与组蛋白甲基化的关系

Development of Histone Methylation and Demethylation

组蛋白甲基化和去甲基化研究进展

And there exists cross-talk among histone methylation and other histone covalent modifications and DNA methylation .

H3-K4、H3-K36、H3-K79甲基化具有激活效应，而且组蛋白甲基化与其它组蛋白共价修饰之间以及DNA甲基化之间存在对话。

The effector proteins are therefore critical for interpreting the methylation codes and thus mediate the biological effect of histone methylation .

这些效应蛋白因此对解释甲基化密码，以及组蛋白甲基化修饰介导的生物学效应是非常关键的。

Histone methylation is an important component of epigenetic regulation , which can regulate gene expression and participate in a variety of biological processes .

组蛋白甲基化是表观遗传调控的一种重要方式，与基因的转录调控密切相关，参与多种生物进程。

As a result , the biological effects of histone methylation are not only determined by the specific sites of methylation but also influenced by the methylation states .

而这些组蛋白甲基化修饰的生物效应不仅仅由特异位点的甲基化修饰决定，还受甲基化修饰的阶段影响。

The discovery of enzymes that reverse histone methylation challenges the current understanding that histone methylation is a stable epigenetic marker and provides a novel way to study histone modifications .

既往认为组蛋白甲基化是稳定的表观遗传标记，而组蛋白去甲基化酶的发现对这一观点提出了挑战，也为进一步深入研究组蛋白修饰提供新的途径。

However , little is known about the functions of histone arginine methylation in plants .

目前关于蛋白质精氨酸甲基转移酶及其催化的精氨酸甲基化修饰在植物发育中的作用还没有任何报道。

The role of histone lysine methylation in the gene expression regulation has turned into the hotspot of epigenetics .

组蛋白赖氨酸甲基化在基因表达调控中的作用已成为表观遗传学研究的热点。

Histone lysine methylation has important functions in many biological processes that include gene expression , X-chromosome inactivation , gene imprinting and DNA repair .

组蛋白赖氨酸甲基化作为共价修饰的一种在基因表达调控、X染色体失活、基因组印迹、DNA修补等生物学过程中起重要作用。

Advance of histone lysine methylation

组蛋白赖氨酸甲基化研究进展

In eukaryotic genes , histones are subject to covalent modifications and histone lysine methylation plays an important role in epigenetics .

在真核基因中，组蛋白会发生多种共价修饰，其中组蛋白的甲基化在表观遗传学中起重要作用。

Histone lysine methylation was originally thought to be permanent , however the finding of histone demethylase suggests the modification process is reversible .

原来认为甲基化是一种稳定修饰，去甲基化酶的发现说明该修饰是可逆的过程。

Effect of Trichostatin A ( TSA ) on Histone Acetylation and Methylation in Bovine Fibroblast Cells

曲古抑菌素A对体外培养牛成纤维细胞组蛋白乙酰化和甲基化的影响

The silenced state is correlated with repressive histone and DNA methylation marks in the D1 promoter region but is not associated with DNA sequence alterations .

基因沉默的这种状态与D1基因启动子中的组蛋白甲基化和DNA甲基化修饰受抑制有关，而不涉及DNA序列的改变。

Histone deacetylation and methylation at lysine 9 of H3 might also contribute to the establishment of DNA methylation patterns . What 's more , the recent studies show that CpG methylation and other histone modifications are correlated .

组蛋白去乙酰化和H3K9甲基化可能有助于DNA甲基化模式的建立，此外，研究结果还显示CpG甲基化和其它组蛋白修饰存在相互作用。

Among various histone modifications identified , histone lysine methylation functions in virtually all chromatin based biological processes including transcriptional regulation and DNA damage repair .

在现有的多种组蛋白修饰中，组蛋白赖氨酸的甲基化实际上参与了所有的以染色质为基础的生物进程，包括转录调控和DNA损伤修复。

The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification .

组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。

Moreover , based on the epigenetic research progress in recent years ," histone code " that is including modification of histone ubiquitination , methylation , acetylation , etc. , plays a crucial role in the regulation of gene transcription .

另外，根据近年来表观遗传学研究进展，组蛋白的泛素化，甲基化，乙酰化等修饰作用共同形成了组蛋白密码，在基因转录调控中起关键性作用。

The identification of more and more histone lysine methyltransferases and effector proteins in recent years has increased our understanding of the functions of histone lysine methylation .

近年来随着更多的组蛋白赖氨酸甲基转移酶及作用蛋白的鉴定，对组蛋白赖氨酸甲基化的功能有了进一步认识。